Estrogen receptor polymorphisms are associated risk factor for mild cognitive impairment and Alzheimer disease in women APOE ε4 carriers
نویسندگان
چکیده
Xabier Elcoroaristizabal Martín, Manuel Fernández-Martínez*, Luis Galdos Alcelay, Fernando Gómez Busto, Maite Álvarez-Álvarez, Ana Molano Salazar A., Rocio Bereincua Gandarias , Sandra Inglés Borda. Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín, Josefa Moraza López, Nuria Ortiz Marqués, María Carrasco Zabaleta, Myriam Barandiarán Amillano, Marian M. de Pancorbo
منابع مشابه
Oestrogen receptor polymorphisms are an associated risk factor for mild cognitive impairment and Alzheimer disease in women APOE ɛ4 carriers: a case–control study
OBJECTIVES Examine the role of single nucleotide polymorphisms (SNPs) in the oestrogen receptor (ER) genes: rs9340799, rs2234693, rs2228480 (in the ESR1 gene) and rs4986938 (in the ESR2 gene) as a risk factor for amnesic mild cognitive impairment (MCIa) and Alzheimer's disease (AD) and its possible association with the apolipoprotein E (APOE) gene. DESIGN We have investigated the independent ...
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BACKGROUND The APOE ε4 allele is a risk factor for Alzheimer's disease (AD). APOE ε4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE ε4 allele and cognitive impairment varied across Northern, Middle and Sout...
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Apolipoprotein E (ApoE) ε4 allele represents a well known vascular risk factor for developing Alzheimer disease (AD) and differences in ApoE genotypes may explain a part of the variability in AD phenotypes. In fact, ApoE ε4 allele possession seems to be associated with a more precocious age of onset, greater episodic memory impairment, and psychotic symptoms. The first question we discuss regar...
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OBJECTIVE Research has reported associations among selected genetic susceptibility biomarkers and risk of (a) normal cognitive aging decrements, (b) established mild cognitive impairment (MCI), and (c) sporadic Alzheimer's disease (AD). In focusing on the transitional normal-to-early MCI phase, we examine associations among three theoretically relevant polymorphisms (APOE [rs429358, rs7412], BD...
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